The NFL season started with a very strong Week 1, filled with surprises and very exciting games. But now we’re onto Week 2, and it’s important not to overreact too much to what we saw last week when making your picks. There is often a lot of flukiness in Week 1 of the NFL season, as these teams are often rusty coming out of the gate, as the offseason has gotten longer, and the preseason has gotten shorter.
Which NFL odds for today’s games represent an overreaction to what we saw last week, and present an opportunity to buy low or sell high on a particular team? Our team of betting experts, including PFN’s Trey Wingo, Chief Content Officer David Bearman, Director of Betting Brian Blewis, and Betting & Fantasy Analysts Kyle Soppe and Jason Katz give their NFL week 2 predictions and picks.
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NFL Week 2 Picks and Predictions
All odds are from DraftKings Sportsbook unless noted otherwise.
Green Bay Packers vs. Atlanta Falcons Prediction
- Spread
Falcons -1.5 - Moneyline
Packers +100, Falcons -120 - Total
40.5 - Game Time
1:00 p.m. EST - Location
Mercedez-Benz Stadium - How To Watch
FOX, Fubo TV, NFL Sunday Ticket
Wingo: Jordan Love and Desmond Ridder had the two highest passer ratings last week, but which quarterback continues that in NFL Week 2?
Love was really impressive vs. Chicago last week, and his official “debut” as the starter in Green Bay was better than Rodgers in 2008 across the board.
Pick: Packers +1.5 (-110 at DraftKings)
Blewis: Trey is right, Jordan Love and the Packers were impressive in their Week 1 win over the Bears. But how much of that was due to the extremely underwhelming Bears’ defense?
This week, they face a much-improved Falcons defense that held the Panthers to 3.9 yards per play last week and might be without their two best playmakers on offense.
Against the Panthers, Bijan Robinson and Tyler Allgeier combined for 25 carries for 131 yards and two touchdowns. I’m expecting another efficient week from this running back duo, as they’re facing a Packers defense that was 31st in success rate in defending the run last season.
I’m predicting a worse day for Love and the Falcons to bleed the clock on the ground. As a result, it will be a low-scoring game in which Desmond Ridder doesn’t have to be much more than a game manager once again.
Pick: Under 40.5 (-110 at DraftKings)
Las Vegas Raiders vs. Buffalo Bills Prediction
- Spread
Bills -8.5 - Moneyline
Raiders +310, Bills -395 - Total
46.5 - Game Time
1:00 p.m. EST - Location
Highmark Stadium - How To Watch
CBS, Fubo TV, Paramount Plus, NFL Sunday Ticket
Wingo: Josh Allen has to perform in what should be a get-right game at home vs. Las Vegas. I’ll take the Bills and the points here.
Pick: Bills -8.5 (-110 at FanDuel)
Bearman: I am probably overreacting to Week 1’s poor and unacceptable Bills performance, but I also said in the preseason that I thought they were a tad overrated and missing something.
That something might just be Josh Allen’s ability to not make mistakes, or it could be another year without a solid running game. Taking QB scrambles out of the equation, the Bills only mustered 61 yards on the ground.
Granted, the Raiders’ defense is not the Jets, and I am not expecting Las Vegas to win this one. But 8.5 points is a lot of points to lay for a team coming off an awful Monday night loss to a Jets team with a backup QB. It’s a good rebound spot for Buffalo for sure, but it’s also too many points when you factor in the fact that Allen has a league-high 46 turnovers since the beginning of the 2021 season.
The Raiders, meanwhile, played a solid game and got the road win at the division-rival Denver Broncos. Again, don’t expect them to force the Bills into 0-2, but I do see them keeping it close.
Pick: Raiders +8.5 (-110 at FanDuel)
Soppe: As we saw MNF wrap up last week, I expected this Bills/Raiders line to open up short. With Vegas coming off of a win in Denver and Buffalo losing a double-digit lead on national TV to Zach Wilson, I approached this game ready to load up on the Bills in a bounce-back spot.
I was wrong. Apparently, no one is buying the Raiders. I’m not here to tell you that they are great, they aren’t. They have plenty of flaws, but keeping games close isn’t one of them, not with Jimmy Jawline under center.
MORE: NFL Survivor Picks Week 2
Since 2019, Jimmy Garoppolo’s team is 32-15 when he throws at least 20 passes. That’s a good place to start and even better is the fact that 10 of those 15 losses came by seven or fewer points.
The 49ers were a bottom-10 in plays per game during Garoppolo’s final two seasons and these Raiders looked similar last week (113 total plays). I like the Raiders to ride Josh Jacobs and melt time off the clock as best they can in this spot. If they cover, it’s not because they out-Buffalo’d Buffalo, it’s because they stayed on the field.
Picks: Raiders +9.5 (-110 at FanDuel), Raiders +9.5 with under 46.5 points (+240 at DraftKings) made earlier this week
Blewis: If a team needed a “get right” spot after Week 1, it’s the Buffalo Bills. Josh Allen couldn’t have played any worse against the Jets last week, but that defense gave him a ton of trouble last season as well. Let’s not let one game forget that he is an elite quarterback.
In games in which they were at least an 8-point favorite last season, the Bills were 6-3 ATS. Take out the two games against the Jets, they went 6-1.
Allen usually feasts on bad teams and bad defenses, and although they nearly shut out the Broncos in the second half last week, this Bills offense will be a much more difficult challenge for the Raiders.
Pick: Bills -8 (-110 at Fanatics) earlier this week
Baltimore Ravens vs. Cincinnati Bengals Prediction
- Spread
Bengals -3.5 - Moneyline
Ravens +142, Bengals -170 - Total
46.5 - Game Time
1:00 p.m. EST - Location
Paycor Stadium - How To Watch
CBS, Fubo TV, Paramount Plus NFL Sunday Ticket
Wingo: The Bengals looked terrible in every way vs. Cleveland last week, and now they get a Ravens team with Lamar Jackson and new weapons.
Burrow has to look much better than he did, and that offensive line has to start protecting him better.
Pick: Ravens +3 (-102 at DraftKings)
Blewis: Last week was a disastrous performance for the Bengals. I picked the Browns (humble brag) but expected it to be a much closer game.
This week, I’m expecting the Bengals to bounce back at home in much better weather conditions. Baltimore is a team that suffered injuries to J.K. Dobbins, Ronnie Stanley, Tyler Linderbaum, and Marcus Williams. Those are four key contributors in addition to Marlon Humphrey, who won’t be suiting up today.
While the Bengals’ offense looked incredibly rusty, the Ravens offense looks to be going through some growing pains under new offensive coordinator Todd Monken as well, and this week, they will be facing a much tougher opponent than the Houston Texans.
Pick: Bengals -3 (-118 at FanDuel)
Seattle Seahawks vs. Detroit Lions Prediction
- Spread
Lions -5 - Moneyline
Seahawks +185, Lions -225 - Total
47.5 - Game Time
1:00 p.m. EST - Location
Ford Field - How To Watch
Fox, Fubo TV, NFL Sunday Ticket
Wingo: This is a big week for Seattle. They got crushed at home, and now head to Detroit which is coming off a mini-bye.
Since Week 9 of last season, the Lions are 9-2, tied with the Kansas City Chiefs for the second-best regular season record behind the San Francisco 49ers.
Pick: Lions -4.5 (-110)
Bearman: Even though they only scored 21 points against the Chiefs, the Lions are going to have one of the best offenses this season and have had 10 days to get ready for a Seattle defense that gave up 31 points to a depleted Rams offense.
I was higher than most on the Rams this year, taking over 6.5 wins, but no one thought they would go up and down the field and score 31 in Seattle. The Lions held the Chiefs to 20, but they were missing Travis Kelce. If Kadarius Toney knew how to catch, it could’ve been 30. This game should go over the 47 and end in the mid-50s.
Pick: Over 47.5 (-110)
Blewis: You will be noticing a theme with my picks is fading the Week 1 overreactions, and this one is the prime example.
The Seahawks were maybe the most disappointing team last week, getting embarrassed by the Rams at home. The game took a terrible turn when starting offensive tackles Charles Cross and Abraham Lucas each left the game with injuries, and this week they’re going against Aidan Hutchinson with a banged-up offensive line.
Still, this line earlier in the week was too big of an overreaction to Week 1. The look-ahead line was Lions -3, and when the spread went up to 6 points, I couldn’t resist taking the Seahawks.
Despite their win in Kansas City to start the season, I wasn’t particularly impressed by the Lions. I’m not putting an asterisk on it like Mike Tirico tried to, but if not for Kadarius Toney they probably lose that game.
Pick: Seahawks +6 (-110 at DraftKings earlier this week)
Los Angeles Chargers vs. Tennessee Titans Prediction
- Spread
Chargers -3 - Moneyline
Chargers -148, Titans +124 - Total
45 - Game Time
1:00 p.m. EST - Location
Nissan Stadium - How To Watch
CBS, Fubo TV, Paramount Plus NFL Sunday Ticket
Soppe: During the Justin Herbert era, the Chargers have seen a league-high 20 games decided by a FG or less, making them a reasonably easy handicap when the spread crosses three points, but we aren’t so lucky this week.
That stat would lean most in the direction of taking the points and getting out of dodge, but I’m going the other way. That stat holds value for most matchups, but not all. The Titans are the bizzaro Chargers in that they are focused on the run game — on both sides of the ball. They stop it at an elite level, and I don’t have to tell you that tackling Derrick Henry is no walk in the park.
With Austin Ekeler banged up (doubtful), the Chargers, behind Kellen Moore, are even more likely to air the ball out against this vulnerable Titans secondary. I happen to trust this offense through the air, and once they put their foot on the gas, the Titans’ offensive game plan is no longer optimal.
The story I’m telling in this game is one of early Charger success, forcing the Titans to pivot away from their offensive strength (and Chargers’ weakness) and putting the ball in the hands of Ryan Tannehill. If I’m right in that projection, this thing could get ugly in a hurry.
Picks: Chargers moneyline (-142 at DraftKings) and Chargers by double digits (+255 at FanDuel)
Katz: The Chargers are a pass-first offense. This week, they’ll be without Austin Ekeler. That is not about to make them more run-heavy.
The Titans are a pass funnel defense, and if the Chargers are not having success on the ground, they will likely lean even more on the pass.
With the better offense and more talented receivers, let’s take a shot on the first touchdown prop here.
Pick: Keenan Allen first touchdown scorer (+950 at DraftKings) as a long shot
Chicago Bears vs. Tampa Bay Buccaneers Prediction
- Spread
Buccaneers -2.5 - Moneyline
Bears +114, Buccaneers -135 - Total
41 - Game Time
1:00 p.m. EST - Location
Raymond James Stadium - How To Watch
FOX, Fubo TV, NFL Sunday Ticket
Katz: If you’ve followed any of my work this past offseason, you know my feelings on Rachaad White. Suffice it to say I am not a fan. But the Bears have a dismal run defense. They were completely gashed by Aaron Jones last week.
The Bucs scored both of their touchdowns through the air last week. That’s not going to happen every week. If they get close to the goal line, for better or worse, White is going to be the guy. We’ve got pretty nice odds on him to score a touchdown this week.
Pick: Rachaad White anytime touchdown (+155 at DraftKings)
Kansas City Chiefs vs. Jacksonville Jaguars Prediction
- Spread
Chiefs -3.5 - Moneyline
Chiefs -185, Jaguars +154 - Total
51 - Game Time
1:00 p.m. EST - Location
EverBank Stadium - How To Watch
CBS, Fubo TV, Paramount Plus, NFL Sunday Ticket
Blewis: I got this line when it dropped to 2.5 earlier this week, which is when you want to back Patrick Mahomes and the Chiefs. In Mahomes’ career as their starting quarterback, the Chiefs are 19-6-1 ATS when the spread is three points or less, regardless of whether they’re the favored or the underdog.
Now that Chris Jones and Travis Kelce are playing and the spread is up to 3.5, that stat doesn’t help you at all (sorry!), but I still would recommend playing the Chiefs here.
We all know that Andy Reid is at his best when he has extra time to prepare. While that didn’t prove to be the case last week, the Chiefs were missing Jones and Kelce, and their loss can almost be chalked up as a fluke thanks to Kadarius Toney.
If there was any weakness for this Jaguars team, it was their defense. They allowed 21 points to an Indianapolis Colts team last week with an extremely raw Anthony Richardson under center and now will be going against Mahomes.
Pick: Chiefs -2.5 (-118 at DraftKings earlier this week)
Indianapolis Colts vs. Houston Texans Prediction
- Spread
Texans -1.5 - Moneyline
Colts +100, Texans -120 - Total
39.5 - Game Time
1:00 p.m. EST - Location
NRG Stadium - How To Watch
Fox, Fubo TV, NFL Sunday Ticket
Blewis: After they opened as the underdogs last Sunday, the Houston Texans are now short home favorites here.
The Texans’ defense looked better than expected against the Ravens last week, but their offense is a major work in progress. The Colts, meanwhile, were leading 21-17 going into the 4th quarter against Jacksonville last week before getting outscored 14-0 to lose the game by double-digits.
None of us have a play in this one, and it’s a game I have no interest in betting or watching. Pass.
San Francisco 49ers vs. Los Angeles Rams Prediction
- Spread
49ers -7.5 - Moneyline
49ers -340, Rams +270 - Total
44.5 - Game Time
4:05 p.m. EST - Location
SoFi Stadium - How To Watch
FOX, Fubo TV, NFL Sunday Ticket
Blewis: The San Francisco 49ers look like the best team in the NFL right now, and it starts on offense. Coming off his elbow injury, Brock Purdy didn’t skip a beat last week in their 30-7 win over the Pittsburgh Steelers.
Although the Rams’ defense shut out the Seahawks in the second half last week, they were going against two backup offensive tackles. I’m not going to overreact to the performance by the Rams defense last week, as this was expected to be one of the worst units in the NFL despite having Aaron Donald.
I’m expecting another lights-out game from this 49ers offense.
Pick: 49ers over 26.5 points (-120 at FanDuel)
Soppe: In what on paper looks like the biggest mismatch of the week, bettors are faced with laying a big number against a home team coming off of an impressive win. That isn’t the most comfortable of situations to be in, so allow me to help.
With Cooper Kupp still on IR and Paka Nacua battling an oblique injury, would it not follow that the Rams will want to shorten this game as much as possible, especially early on? They managed only 92 yards on the ground last week, but they did run it 40 times. I expect more of the same in this spot: volume attempts with little success.
The game plan of limiting the possession count and burning the clock is fine, and it may work early on. In the first half, they won’t be as game script dependent, thus leading me to believe that the second half is where the 49ers truly impose their will.
San Francisco’s hyper-efficient offense should be just fine against this undermanned Rams defense, and one early score could put us in a great position with this small SGP.
Pick: 49ers win the first half, Rams under 9.5 first-half points, and the 49ers win the game (+121 at FanDuel)
New York Giants vs. Arizona Cardinals Prediction
- Spread
Giants -4 - Moneyline
Giants -218, Cardinals +180 - Total
40 - Game Time
4:05 p.m. EST - Location
State Farm Stadium - How To Watch
Fox, Fubo TV, NFL Sunday Ticket
Bearman: It won’t get much worse than a 40-0 blowout loss in primetime at home. But as we all know, that counts only as one loss.
I thought the Giants overachieved last year and predicted a slight fallback this year, but they are better than what they showed on Sunday night.
People probably don’t even remember, but Daniel Jones and the Giants drove the ball right down the field after the opening coin toss and had a 3rd and 2 at the Cowboys 8-yard line before a false start, a horrible snap over Jones’ head, and a blocked field goal for a touchdown changed the dynamic of the game.
I’m not saying they would have won, but it would not have been 40-0.
Anyhow, in come the Arizona Cardinals, who fought hard before losing to Washington last week, but still have arguably the worst roster in football.
I’ve told people many times that my favorite thing to be in the NFL is Week 2 overreactions, and you have one here.
Pick: Giants -4 (-110 at DraftKings)
Soppe: Sometimes betting can be complicated and other times, not so much. The Cardinals were more competitive last week than most assumed against the Commanders, while the Giants remained competitive with the Cowboys for less than 13 minutes in an island game. Buy the dip.
The Giants held the Cowboys to under five yards per play in their embarrassing season-opening loss, a rate that should carry over against the talent-void Cardinals. New York also has a dynamic running game, something Washington didn’t have last week (28 carries for 92 yards with their longest effort being seven yards), something that should allow them to dictate the tempo and play with a lead.
Nothing the Cardinals did last week changed my opinion of them as being the worst team in football (6.3 yards per completion is downright offensive) and while I don’t think the Giants are a threat to win the NFC East, they aren’t nearly the dumpster fire that we saw last weekend.
Pick: Giants -4 (-110 at DraftKings)
New York Jets vs. Dallas Cowboys Prediction
- Spread
Cowboys -9.5 - Moneyline
Jets +340, Cowboys -440 - Total
38.5 - Game Time
4:25 p.m. EST - Location
AT&T Stadium - How To Watch
CBS, Fubo TV, Paramount Plus, NFL Sunday Ticket
Bearman: Zach Wilson vs. arguably the top defense in football spells under to me.
The Cowboys’ offense didn’t exactly light up the scoreboard vs. the Giants last week, but they also didn’t need to with multiple defensive touchdowns.
Without Aaron Rodgers, I don’t expect the Jets to be able to move the ball much. This has the makings of a 17-10 game, but with the Cowboys’ ability to force turnovers, you never know.
Lean: Under 38.5 (-110 at DraftKings)
Washington Commanders vs. Denver Broncos Prediction
- Spread
Broncos -3.5 - Moneyline
Commanders +150, Broncos -180 - Total
39 - Game Time
4:25 p.m. EST - Location
Empower Field at Mile High - How To Watch
CBS, Fubo TV, Paramount Plus, NFL Sunday Ticket
Katz: Last year, Russell Wilson looked cooked. This year, there was some hope that Sean Payton could revive him. After Week 1, it looks like Wilson is cooked.
Wilson attempted a healthy 34 passes last week but only managed to amass 177 yards on 27 completions. That’s just 5.2 yards per attempt. Everything he threw was short.
Even with Jerry Jeudy back this week, I don’t anticipate Wilson suddenly pushing the ball downfield. Furthermore, a winnable matchup against the Commanders is not going to force Wilson into a negative game script.
Pick: Russell Wilson under 226.5 passing yards (-115 at BetMGM)
Miami Dolphins vs. New England Patriots Prediction
- Spread
Dolphins -3 - Moneyline
Dolphins -155, Patriots +130 - Total
46.5 - Game Time
8:20 p.m. EST - Location
Gillette Stadium - How To Watch
NBC, Peacock
Bearman: The Chargers, who shut down the Dolphins and Tua in 2022, watched Miami put up 36 points and over 500 yards of offense. The high-flying offense moves to the northeast and is only lying 2 vs. the Patriots.
New England’s defense looked good in Week 1 bottling up Jalen Hurts and the Eagles, but they have yet to figure Tua out. The Dolphins are 4-0 vs. the Patriots with Tua at the helm, and I don’t see that changing. And now he has his most weapons and runs an offense on a mission.
Trips to Gillette haven’t been pretty, but neither is trying to stop this offense.
Best Bet: Dolphins -2 (-115 at FanDuel earlier this week)
Soppe: Maybe this is me holding onto a prior, but I wasn’t impressed with the Patriots last week. Yes, I understand they kept things close with the reigning NFC Champions, but it didn’t come in the most sustainable of ways.
In Week 1, New England didn’t have a player run for 30 yards or receive for 65. They had a single chunk of play and asked their game-managing quarterback to throw the ball 54 times. They had not one, but two stretches of 25-plus minutes in which they did not score a single point. What about that inspires confidence that they are better than we thought?
I will grant you that the Dolphins didn’t exactly put up a strong defensive showing in their Week 1 win, but I expect that Vic Fangio unit to improve with time. I also expect them to improve when playing a team void of playmakers, a situation that is the case this week and wasn’t last.
Pick: Patriots team total under 22.5 (-108 at FanDuel)
New Orleans Saints vs. Carolina Panthers Prediction
- Spread
Saints -3 - Moneyline
Saints -162, Panthers +136 - Total
40 - Game Time
7:15 p.m. EST - Location
Bank of America Stadium - How To Watch
ESPN, ESPN2
Soppe: Last season, the Panthers, despite a schedule with subpar quarterback talent on the opposition, ranked 21st in preventing yards per pass. That alone would mean targeting them through the air as an option, and with 2021 first-round pick Jaycee Horn on IR (hamstring), this is a good spot to load up on the Saints.
In Week 1, Rashid Shaheed again showcased his game-breaking abilities. With Derek Carr’s aDOT continuing to trend up (second highest in Week 1), the 4.3 speed of Shaheed is a weapon of mass destruction. He has a 30-plus yard grab in seven of his past 11 games and has been efficient in his young career (33 catches on 40 targets).
Picks: Rashid Shaheed over 36.5 receiving yards (-125 at DraftKings), Shaheed to record 50+ receiving yards (+165 at DraftKings)
Cleveland Browns vs. Pittsburgh Steelers Prediction
- Spread
Browns -2.5 - Moneyline
Browns -135, Steelers +114 - Total
39 - Game Time
8:15 p.m. EST - Location
Acrisure Stadium - How To Watch
ABC/ESPN+
Soppe: Any game evaluation has to start at the quarterback position in 2023, and in this game, we have a pair of quarterbacks capable of making big plays, and big mistakes. Neither looked great in Week 1, but both are not shy to challenge down the field, and both have capable, big-play receivers that encourage them to do so.
Both of these defenses were bottom-12 in opponent score rate last season, another factor that could lead to some big plays. Sure, the Browns’ defense looked good in poor weather conditions against a quarterback in Joe Burrow, who hadn’t played in a month. But I’m not yet sold on them as an elite unit. The Steelers showed no signs of resistance against the 49ers (5.9 yards per play).
Six of the past seven meetings between these divisional rivals have seen at least 40 points scored, and I think we make it seven of eight on Monday night.
Pick: Over 39.5 points (-110 at DraftKings)
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