The 4-1 San Francisco 49ers head into Sunday’s matchup against the Tampa Bay Buccaneers facing a crucial test against another 4-1 team.
Tampa Bay brings one of the league’s most explosive passing attacks, led by quarterback Baker Mayfield, who has been playing at an elite level this season.
The challenge grows more complicated for San Francisco as starting quarterback Brock Purdy remains sidelined with a toe injury that has already cost him three games.
Initial optimism about Purdy’s potential return this weekend has diminished, leaving the 49ers in an uncertain position at the most critical spot on the field.
“49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday’s game at Tampa Bay. 49ers QB Mac Jones starts again,” ESPN’s Adam Schefter shared.
49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday’s game at Tampa Bay.
49ers QB Mac Jones starts again. pic.twitter.com/7FQglh7QKN
— Adam Schefter (@AdamSchefter) October 10, 2025
Jones has proven himself capable during this stretch, starting the season 3-0 while completing 66.7% of his passes for 905 yards, six touchdowns, and just one interception.
The 2021 first-round pick currently leads the team in both pass attempts and completions per game, displaying his sharpest form since his rookie campaign with the Patriots.
That 2021 season saw him complete 67.5% of throws for 3,801 yards, 22 touchdowns, and 13 interceptions across a full year.
The efficiency Jones has shown recently raises legitimate questions about his ability to maintain this production level against stronger opponents over an extended period.
This matchup against Mayfield’s high-powered passing game will provide a significant measuring stick for where Jones stands as a consistent starter.
San Francisco’s injury situation extends well beyond the quarterback position and could ultimately determine how they approach this game offensively.
Nick Bosa is done for the season following a torn ACL, while George Kittle will miss at least another game dealing with a hamstring issue.
Receivers Ricky Pearsall, Jauan Jennings, and Brandon Aiyuk have all missed time as well, creating real pressure across the offensive depth chart.
